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Annotated patent selections.

Expert opinion on therapeutic patents

Norman P.
PMID: 20141504
Expert Opin Ther Pat. 2005 Jun;15(6):715-39. doi: 10.1517/13543776.15.6.715.

No abstract available.

The sulfamide motif in the design of enzyme inhibitors.

Expert opinion on therapeutic patents

Winum JY, Scozzafava A, Montero JL, Supuran CT.
PMID: 20141508
Expert Opin Ther Pat. 2006 Jan;16(1):27-47. doi: 10.1517/13543776.16.1.27.

The sulfamide moiety, similarly to the structurally related sulfonamide and sulfamate ones, is widely employed in medicinal chemistry for the design of biologically active compounds. Amongst the enzymes for which sulfamide-based inhibitors were designed are the carbonic anhydrases (CAs),...

Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth.

Expert opinion on therapeutic patents

Nieto-Sampedro M, Doncel-Pérez E, Fernández-Mayoralas A.
PMID: 21793650
Expert Opin Ther Pat. 2004 Apr;14(4):487-97. doi: 10.1517/13543776.14.4.487.

Neurostatin, a natural glycosphingolipid inhibitor of astroblast and astrocytoma division, present in mammalian brain, is the modified ganglioside O-acetylated GD1b. It is cytostatic for rat astroblasts, C6 glioma cells and various human astrocytoma lines grades III and IV, with...

Corticotropin-releasing factor receptor antagonists.

Expert opinion on therapeutic patents

Gilligan PJ.
PMID: 20144054
Expert Opin Ther Pat. 2006 Jul;16(7):913-24. doi: 10.1517/13543776.16.7.913.

Corticotropin-releasing factor (CRF) coordinates the neural, endocrine and immune responses of the body to stress. Therefore, CRF receptors are important targets for the design of drugs for depression, anxiety and stress-related disorders. Several laboratories have published extensive preclinical and...

Adenovirus-vectored vaccines.

Expert opinion on therapeutic patents

Chawla T, Khanna N, Swaminathan S.
PMID: 20144086
Expert Opin Ther Pat. 2008 Mar;18(3):293-307. doi: 10.1517/13543776.18.3.293.

BACKGROUND: Engineered adenoviruses are being increasingly explored as immunoprophylactic or immunotherapeutic vaccine vectors. Encouraging data from preclinical studies using human adenovirus vectors carrying different antigen genes have resulted in many currently ongoing clinical trials.OBJECTIVE: The article seeks to review...

Dihydrofolate reductase inhibitors: developments in antiparasitic chemotherapy.

Expert opinion on therapeutic patents

Bolstad DB, Bolstad ES, Wright DL, Anderson AC.
PMID: 20553119
Expert Opin Ther Pat. 2008 Feb;18(2):143-57. doi: 10.1517/13543776.18.2.143.

BACKGROUND: Infections caused by parasitic protozoa present a growing health concern, particularly in developing parts of the world. Although malaria is clearly the most well-known and deadly of these diseases, infections caused by other parasites, such as Toxoplasma, Cryptosporidia...

Inventors and their attorneys must beware of their actions before the US Patent and Trademark Office.

Expert opinion on therapeutic patents

Warburg R, Nguyen L.
PMID: 21793649
Expert Opin Ther Pat. 2004 Apr;14(4):453-6. doi: 10.1517/13543776.14.4.453.

Inventors and their legal representative have a duty to disclose all material information of which they are aware to the United States Patent and Trademark Office (USPTO). Breach of this duty, combined with an intent to deceive the USPTO,...

Marine natural products as source of new drugs: an updated patent review (July 2018-July 2021).

Expert opinion on therapeutic patents

Banerjee P, Mandhare A, Bagalkote V.
PMID: 34872430
Expert Opin Ther Pat. 2022 Jan 05;1-47. doi: 10.1080/13543776.2022.2012150. Epub 2022 Jan 05.

INTRODUCTION: Marine natural products have aided as rich sources of new bioactive agents. The multiplicity of marine habitations and exclusive ecological conditions of the sea offer mostly unexploited sources of unique biological and chemical entities. In continuation with the...

Expert opinion on therapeutic patents

Marichev KO, Patil SA, Patil SA, Heras Martinez HM, Bugarin A.
PMID: 34365884
Expert Opin Ther Pat. 2021 Aug 18;1-15. doi: 10.1080/13543776.2021.1965992. Epub 2021 Aug 18.

INTRODUCTION: Besides the well-established catalytic, synthetic and materials related applications of N-heterocyclic carbene (NHC) metal complexes, their use as therapeutics deserves a special attention. Many literature reports indicate that their bioactivity is superior to other organometallic compounds. The main...

Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019-2021).

Expert opinion on therapeutic patents

Gonzalez Lopez de Turiso F, Guckian K.
PMID: 35001782
Expert Opin Ther Pat. 2022 Jan 10; doi: 10.1080/13543776.2022.2026927. Epub 2022 Jan 10.

INTRODUCTION: Tyrosine kinase 2 (TYK2) is a member of the JAK family class of kinases that is responsible for mediating the immune response to IL-12, IL-23, and IFNα. The therapeutic value of targeting this pathway in autoimmune diseases is...

Selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs): a patent review (2015-present).

Expert opinion on therapeutic patents

Scott JS, Barlaam B.
PMID: 34763600
Expert Opin Ther Pat. 2021 Nov 11; doi: 10.1080/13543776.2022.2006185. Epub 2021 Nov 11.

INTRODUCTION: The estrogen receptor (ER) is a clinically validated oncology target with a pivotal role in hormonally driven breast cancer, the most prevalent form of female cancer. Current treatments which directly modulate ER include antagonists (SERMs), such as tamoxifen,...

An updated patent review of small-molecule c-Met kinase inhibitors (2018-present).

Expert opinion on therapeutic patents

Chu C, Rao Z, Pan Q, Zhu W.
PMID: 34791961
Expert Opin Ther Pat. 2021 Nov 29;1-20. doi: 10.1080/13543776.2022.2008356. Epub 2021 Nov 29.

INTRODUCTION: c-Met tyrosine kinase receptor is a high-affinity ligand of hepatocyte growth factor (HGF). c-Met is widely expressed in a variety of normal human tissues, but shows abnormally high expression, amplification or mutation in tumour tissues such as lung,...

Showing 1 to 12 of 104 entries